Effect of soft coral extracts on isolated tissues
Abstract
Methanolic extracts of eleven species of soft corals collected from Lakshwadeep islands in the Arabian Sea and Mandapam in the east coast of India were tested for their antispasmodic, antiarrhythmic and oxytocic activity on guinea pig ileum, atrium and uterus respectively. Lobophytum schoedei caused a decrease in nictotine induced contration. L. denticulatum and Sinularia leptoclados caused a dose-dependent decrease in all spasmogens tested (acetylcholine, histamine, 5-hydroxytryptamine, nicotine and barium chloride). Cladiella pachyclados and C. kremfi collected from Kalpeni and Kadamath Islands showed difference in activity. None of the soft corals exhibited any anti-arrhythmic property on guinea pig atrium.
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