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dc.contributor.authorThakur, N.L.
dc.contributor.authorHentschel, U.
dc.contributor.authorKrasko, A.
dc.contributor.authorPabel, C.T.
dc.contributor.authorAnil, A.C.
dc.contributor.authorMueller, W.E.G.
dc.date.accessioned2008-07-18T05:07:18Z
dc.date.available2008-07-18T05:07:18Z
dc.date.issued2003
dc.identifier.citationAquatic Microbial Ecology, Vol.31; 77-83p.
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/1203
dc.description.abstractThe epibacterial chemical defense of the marine sponge Suberites domuncula was explored by screening sponge extract, sponge primmorph (3-D aggregates containing proliferating cells) extract and sponge-associated as well as primmorph-associated bacteria for antibacterial activity. 16S rDNA sequencing revealed that the antimicrobially active bacteria belonged to the alpha- and gamma-subdivisions of Proteobacteria (alpha-Proteobacterium MBIC 3368, Idiomarina sp. and Pseudomonas sp., respectively). Moreover, a recombinant perforin-like protein was cloned from S. domuncula that displayed strong antibacterial activity. Based on these observations, it is proposed that the sponge may be provided with a direct (by producing antibacterial metabolites) as well as an indirect (with the help of associated bacteria) epibacterial defense.
dc.language.isoen
dc.publisherInter Research
dc.rightsCopyright [2003]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
dc.subjectmarine invertebrates
dc.subjectantibiotics
dc.subjectdefence mechanisms
dc.subjectprotective behaviour
dc.subjectbacterial diseases
dc.subjectproteins
dc.subjectcloning
dc.subjectmetabolites
dc.subjectSuberites domuncula
dc.titleAntibacterial activity of the sponge Suberites domuncula and its primmorphs: Potential basis for epibacterial chemical defense
dc.typeJournal Article


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