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dc.contributor.authorShailaja, M.S.
dc.contributor.authorDeSilva, C.
dc.date.accessioned2008-07-18T05:52:45Z
dc.date.available2008-07-18T05:52:45Z
dc.date.issued2003
dc.identifier.citationChemosphere, Vol.53; 835-841p.
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/1269
dc.description.abstractTreatment of the widely occurring tropical cichlid, Oreochromis mossambicus with a pure polycyclic aromatic hydrocarbon (PAH), phenanthrene, induced a concentration-dependant formation of the enzyme, 7-ethoxyresorufin-O-deethylase (EROD). Concomittant increase (65-669%) in the activity of sorbitol dehydrogenase in the serum (SSDH) occurring with EROD induction denoted liver cell damage, which was more severe in fish exposed to lower concentrations (0.4-4 mu g g u-1) of the chemical. In O. mossambicus exposed to 25% refinery effluent liver damage associated with cell death was indicated by the twin analyses of SSDH and liver somatic index. Cell injury appeared to have occurred at low PAH concentrations due to inadequately induced phase II-related detoxification of metabolites. This was indicated by the nearly 33% higher activity of hepatic glutathione S-transferase (GST) in fish exposed to higher PAH concentrations as compared to low-exposure animals. Tilapia such as O. mossambicus were found to be eminently suited for biomonitoring in tropical coastal waters. A combination of EROD and serum sorbitol dehydrogenase activity measurements serves as an excellent tool for biomonitoring sublethal effects of PAH pollution in fish.
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright [2003]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
dc.subjectbrackishwater fish
dc.subjectsublethal effects
dc.subjectpollution effects
dc.subjectaromatic hydrocarbons
dc.subjectbiomarkers
dc.subjectOreochromis mossambicus
dc.titleEvaluation of impact of PAH on a tropical fish, Oreochromis mossambicus using multiple biomarkers
dc.typeJournal Article


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