T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria

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dc.contributor.author Gowda, N.M.
dc.contributor.author Goswami, U.
dc.contributor.author Khan, M.I.
dc.date.accessioned 2008-11-25T09:26:08Z
dc.date.available 2008-11-25T09:26:08Z
dc.date.issued 2008
dc.identifier.citation Journal of Invertebrate Pathology, vol.99; 141-145p.
dc.identifier.uri http://drs.nio.org/drs/handle/2264/1499
dc.description.abstract In invertebrates, cellular and humoral components are evolved to maintain their body immunity and integrity. Both these factors respond to different antigens such as microorganisms, vertebrate erythrocytes and foreign proteins. In this article, we report a study of a lectin (HSL) involved in immune response in the echinoderm, sea cucumber (Holothuria scabra). Correlative studies indicate that the expression of this defensive lectin is induced by bacterial challenge, wherein cell wall glycoconjugates of bacteria are involved in lectin induction. HSL showed strong broad spectrum antibacterial activity against both grampositive and gram-negative bacteria. Under in vitro conditions, purified HSL mediate agglutination of the test bacteria, there by indicating a possible mode of action in physiological situation.
dc.language.iso en
dc.publisher Elsevier
dc.rights Copyright [2008]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
dc.subject marine invertebrates
dc.subject coelomic fluids
dc.subject Holothuria scabra
dc.subject antibiotics
dc.title T-antigen binding lectin with antibacterial activity from marine invertebrate, sea cucumber (Holothuria scabra): Possible involvement in differential recognition of bacteria
dc.type Journal Article


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