An expeditious I sub(2)-catalyzed entry into 6H-indolo[2,3-b]quinoline system of cryptotackieine
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Date
2009Author
Parvatkar, P.T.
Parameswaran, P.S.
Tilve, S.G.
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A synthesis of a series of novel 6H-indolo[2,3-b]- quinolines with different substituents on the quinoline ring is described. The method involves reaction of indole-3-carboxyaldehyde with aryl amines in the presence of a catalytic amount of iodine in refluxing diphenyl ether to yield indolo[2,3-b]quinolines in one-pot. The present approach provides a new route for the synthesis of polycyclic structures related to an alkaloid cryptotackieine (neocryptolepine)
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