CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

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dc.contributor.author Ravindran, C.
dc.contributor.author Cheng, Y.-C.
dc.contributor.author Liang, S.-M.
dc.date.accessioned 2010-04-04T14:19:43Z
dc.date.available 2010-04-04T14:19:43Z
dc.date.issued 2010
dc.identifier.citation Cellular Immunology, vol.260(2); 113-118
dc.identifier.uri http://drs.nio.org/drs/handle/2264/3573
dc.description.abstract Unmethylated CpG oligodeoxynucleotides (CpG-ODNs) interact with Toll-like receptor (TLR) 9 to activate macrophage/microglia in central nervous system (CNS). The potential involvement of the chemokine CCL9 and its receptor CCR1 in the effects of CpG-ODNs on macrophage/microglial cells are investigated. CpG-ODNs enhanced the expression of TLR9 mRNA of RAW264.7 macrophage and BV2 microglia cells time dependently. The expression of CCL9 of macrophages/microglia showed different responsiveness upon stimulation with a variety of CpG-ODN sequences. The CpG-ODNs-mediated induction of CCL9 was TLR9/MyD88 dependent and associated with activation of stress kinases, particularly ERK, p38 MAPK and PI3K. The expression of CCR1 was also significantly increased by CpG-ODNs that increased CCL9 expression. These results reveal the potential involvement of CCL9 and CCR1 in regulation of macrophage and microglial cells by CpG-ODNs and may help improving our understanding about the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions
dc.language.iso en
dc.publisher Elsevier
dc.rights An edited version of this paper was published by Elsevier. Copyright [2010] Elsevier
dc.subject microglial cells
dc.subject oligodeoxynucleotides
dc.subject Amyloid beta
dc.subject CpG-ODNs
dc.title CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia
dc.type Journal Article

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