dc.contributor.author | Ravindran, C. | |
dc.contributor.author | Cheng, Y.-C. | |
dc.contributor.author | Liang, S.-M. | |
dc.date.accessioned | 2010-04-04T14:19:43Z | |
dc.date.available | 2010-04-04T14:19:43Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Cellular Immunology, vol.260(2); 113-118 | |
dc.identifier.uri | http://drs.nio.org/drs/handle/2264/3573 | |
dc.description.abstract | Unmethylated CpG oligodeoxynucleotides (CpG-ODNs) interact with Toll-like receptor (TLR) 9 to activate macrophage/microglia in central nervous system (CNS). The potential involvement of the chemokine CCL9 and its receptor CCR1 in the effects of CpG-ODNs on macrophage/microglial cells are investigated. CpG-ODNs enhanced the expression of TLR9 mRNA of RAW264.7 macrophage and BV2 microglia cells time dependently. The expression of CCL9 of macrophages/microglia showed different responsiveness upon stimulation with a variety of CpG-ODN sequences. The CpG-ODNs-mediated induction of CCL9 was TLR9/MyD88 dependent and associated with activation of stress kinases, particularly ERK, p38 MAPK and PI3K. The expression of CCR1 was also significantly increased by CpG-ODNs that increased CCL9 expression. These results reveal the potential involvement of CCL9 and CCR1 in regulation of macrophage and microglial cells by CpG-ODNs and may help improving our understanding about the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights | An edited version of this paper was published by Elsevier. Copyright [2010] Elsevier | |
dc.subject | microglial cells | |
dc.subject | oligodeoxynucleotides | |
dc.subject | Amyloid beta | |
dc.subject | CpG-ODNs | |
dc.title | CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia | |
dc.type | Journal Article | |