Statins: 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors demonstrate anti-atherosclerotic character due to their antioxidant capacity

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dc.contributor.author Puttananjaiah, M.H.
dc.contributor.author Dhale, M.A.
dc.contributor.author Gaonkar, V.
dc.contributor.author Keni, S.
dc.date.accessioned 2011-03-09T10:56:07Z
dc.date.available 2011-03-09T10:56:07Z
dc.date.issued 2011
dc.identifier.citation Applied Biochemistry and Biotechnology, vol.163(2); 2011; 215-222
dc.identifier.uri http://drs.nio.org/drs/handle/2264/3812
dc.description.abstract Atherosclerosis is a chronic inflammatory disease of multiple etiologies. It is associated with the accumulation of oxidized lipids in arterial lesions leading to coronary heart disease. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (commonly known as statins) are widely used in cardiovascular disease prevention to lower the cholesterol. The antioxidant activity of HMG-CoA reductase inhibitors was studied by lipid peroxidation inhibition assay, DPPH, and hydroxyl radical scavenging-activity methods. The lovastatin (93%) and simvastatin (96%) showed significant action of lipid peroxidation inhibition compared to other HMG-CoA reductase inhibitors. The DPPH radical and hydroxyl radical scavenging activity of simvastatin was 38% and 33%, respectively. The oxidative modification of serum lipid due to reactive oxygen species causes atherosclerosis. This study revealed the importance of lovastatin and simvastatin to prevent oxidative stress-related cardiovascular diseases
dc.language.iso en
dc.publisher Springer
dc.rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2011] Springer.
dc.subject Antioxidant
dc.subject Lipid peroxidation
dc.subject Hydroxyl radical
dc.subject Atherosclerosis
dc.title Statins: 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors demonstrate anti-atherosclerotic character due to their antioxidant capacity
dc.type Journal Article


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