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dc.contributor.authorRavindran, C.
dc.contributor.authorVaratharajan, G.R.
dc.contributor.authorRajasabapathy, R.
dc.contributor.authorVijayakanth, S.
dc.contributor.authorHarishKumar, A.
dc.contributor.authorMeena, R.M.
dc.date.accessioned2012-08-21T06:07:00Z
dc.date.available2012-08-21T06:07:00Z
dc.date.issued2012
dc.identifier.citationMicrobial Pathogenesis, vol.53; 2012; 168-179
dc.identifier.otherno
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4118
dc.description.abstractSalinity tolerance a key factor helps in understanding the ionic homeostasis in general is a fundamental cellular phenomenon in all living cells. A marine derived pathogenic fungus was examined for its adaptation under salt stress using antioxidant properties. The aqueous extracts of halophilic fungus exhibited different levels of antioxidant activity in all the in vitro tests such as alpha, alpha-diphenyl-beta-picrylhydrazyl (DPPH'), Hydroxyl Radical Scavenging Assay (HRSA), Metal chelating assay and beta-carotene-linoleic acid model system. The antioxidant capacity of marine fungus exposed to high salt condition showed an increase in activity. In addition, the production of intra and extracellular antioxidant enzymes of the fungus at various salt stresses were analyzed and discussed for their possible role in the stress mechanism. The marine derived fungus was identified as Phialosimplex genus, which is associated with infections in dogs. Thus the present study elucidates that the scavenging activity is one of the protective mechanisms developed in the fungus to avoid the deleterious effect of salt stress. In addition, the study also helps in understanding how the pathogenic fungus tackles the oxidative burst i.e. hypersensitivity reaction performed by host to kill the pathogens.
dc.language.isoen
dc.publisherElsevier
dc.relation.requiresMicrob_Pathogenesis_53_168.jpg
dc.rightsAn edited version of this paper was published by Elsevier. Copyright [2012] Elsevier
dc.subjectfungi
dc.subjectpathogens
dc.subjectantioxidants
dc.titleA role for antioxidants in acclimation of marine derived pathogenic fungus (NIOCC 1) to salt stress
dc.typeJournal Article


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