Chemistry of the nudibranch Aldisa andersoni: Structure and biological activity of phorbazole metabolites

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dc.contributor.author Nuzzo, G.
dc.contributor.author Ciavatta, M.L.
dc.contributor.author Kiss, R.
dc.contributor.author Mathieu, V.
dc.contributor.author Leclercqz, H.
dc.contributor.author Manzo, E.
dc.contributor.author Villani, G.
dc.contributor.author Mollo, E.
dc.contributor.author Lefranc, F.
dc.contributor.author DeSouza, L.
dc.contributor.author Gavagnin, M.
dc.contributor.author Guido Cimino, G.
dc.date.accessioned 2012-09-03T09:05:39Z
dc.date.available 2012-09-03T09:05:39Z
dc.date.issued 2012
dc.identifier.citation Marine Drugs, vol.10; 2012; 1799-1811
dc.identifier.uri http://drs.nio.org/drs/handle/2264/4143
dc.description.abstract A chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.
dc.language.iso en
dc.publisher MDPI Publishing
dc.rights OPEN ACCESS
dc.subject growth regulators
dc.subject inhibitors
dc.subject feeding behaviour
dc.subject Aldisa andersoni
dc.title Chemistry of the nudibranch Aldisa andersoni: Structure and biological activity of phorbazole metabolites
dc.type Journal Article


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