Modulation of LPS induced inflammatory response by Lawsonyl monocyclic terpene from the marine derived Streptomyces sp.

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dc.contributor.author Ali, A.
dc.contributor.author Khajuria, A.
dc.contributor.author Sidiq, T.
dc.contributor.author AshokKumar
dc.contributor.author Thakur, N.L.
dc.contributor.author Naik, D.
dc.contributor.author Vishwakarma, R.A.
dc.date.accessioned 2013-04-01T09:54:49Z
dc.date.available 2013-04-01T09:54:49Z
dc.date.issued 2013
dc.identifier.citation Immunology Letters, vol.150; 2013; 79-86
dc.identifier.uri http://drs.nio.org/drs/handle/2264/4265
dc.description.abstract In continuing research for compounds with immunosuppressive activity, Lawsonone (1), a novel Lawsonyl derivative isolated from marine-derived bacteria Streptomyces sp. was evaluated for its potent immunosuppressive activity on immune system. The effect of Lawsonone (1) was elucidated on the immune cells (splenocytes and macrophages) collected from BALB/c mice. Study was carried out to find the effect of Lawsonone (1) on Con-A and LPS stimulated splenocyte proliferation, LPS-induced NO, IL-1beta, IL-6 and TNF-alpha production in macrophages. Furthermore, the effect of Lawsonone (1) on T-cell subsets (CD4 and CD8) and total B-cell (CD19) population was analyzed by flow cytometry. The results obtained in the present study showed that Lawsonone (1) inhibited the proliferation of both T and B splenocytes. It inhibited the nitric oxide (NO) and pro-inflammatory cytokine (IL-1beta, IL-6 and TNF-alpha) production in LPS-stimulated macrophages in a dose-dependent manner. Moreover, flow cytometric analysis indicated the prominent inhibition of CD4, CD8 and CD19 cell populations in the spleen of mice treated with the variable doses of Lawsonone (1), with the maximum inhibition at the lowest dose (0.1 mu M). Taken together, the present results suggest that Lawsonone (1) may act as a potent molecule for immunosuppression and anti-inflammation, supporting its immunopharmacologic application to modify the immune system.
dc.language.iso en
dc.publisher Elsevier
dc.rights An edited version of this paper was published by Elsevier. Copyright [2013] Elsevier
dc.subject pharmacology
dc.subject phytohormones
dc.subject macrophages
dc.subject Streptomyces sp.
dc.title Modulation of LPS induced inflammatory response by Lawsonyl monocyclic terpene from the marine derived Streptomyces sp.
dc.type Journal Article


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