Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa

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dc.contributor.author Majik, M.S.
dc.contributor.author Naik, D.
dc.contributor.author Bhat, C.
dc.contributor.author Tilve, S.
dc.contributor.author Tilvi, S.
dc.contributor.author DeSouza, L.
dc.date.accessioned 2013-04-02T10:03:15Z
dc.date.available 2013-04-02T10:03:15Z
dc.date.issued 2013
dc.identifier.citation Bioorganic & Medicinal Chemistry Letters, vol.23; 2013; 2353-2356
dc.identifier.other no
dc.identifier.uri http://drs.nio.org/drs/handle/2264/4277
dc.description.abstract (R)-Bgugaine is a natural pyrrolidine alkaloid from Arisarum vulgare, which shows antifungal and antibacterial activity. We have accomplished the simple synthesis of norbgugaine (demethylated form of natural bgugaine) employing Wittig olefination and cat hydrogenation as the key steps and its biological studies are reported for the first time. The synthesized norbgugaine was evaluated for inhibition of quorum sensing mediated virulence factors (motility, biofilm formation, pyocyanin pigmentation, rhamnolipid production and LasA protease) in Pseudomonas aeruginosa wherein swarming motility is reduced by 95 percent, and biofilm formation by 83 percent.
dc.language.iso en
dc.publisher Elsevier
dc.relation.requires Bioorg_Med_Chem_Lett_23_2353.jpg
dc.rights An edited version of this paper was published by Elsevier. Copyright [2013] Elsevier
dc.subject inhibitors
dc.subject antibiotics
dc.subject fungicides
dc.subject antifouling substances
dc.title Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa
dc.type Journal Article


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