Antioxidative metabolites synthesized by marine pigmented vibrio sp. and its protection on oxidative deterioration of membrane lipids

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dc.contributor.author Pawar, R.T.
dc.contributor.author Mohandass, C.
dc.contributor.author Dastager, S.G.
dc.contributor.author Kolekar, Y.M.
dc.contributor.author Malwankar, R.
dc.date.accessioned 2016-07-11T09:17:33Z
dc.date.available 2016-07-11T09:17:33Z
dc.date.issued 2016
dc.identifier.citation Applied Biochemistry and Biotechnology, vol.179(1); 2016; 155-167
dc.identifier.other no
dc.identifier.uri http://drs.nio.org/drs/handle/2264/4990
dc.description.abstract Bacterial strain Vibrio sp. (PIGB 184) isolated from water samples of the Arabian Sea and identified through 16S rRNA demonstrated the production of pigmentary antioxidants with higher ABTS activities 90.9±0.42 % in comparison with the standard commercial pigmented antioxidant, quercetin 88.8±1.4%. Antioxidative metabolites of this strain substantially inhibit the lipid peroxidation (LPO) reactions tested in sheep liver and brain. The antioxidant compounds produced by the Vibrio sp. (PIGB 184), analysed by GC-MS, reveals that it is composed mostly of phenol, 2,4-bis(1,1-dimethylethyl) and pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-3-(2-methylpropyl). The interrelationship assessed between LPO and the phenolic compounds showed significant correlation with anti-LPO properties (R<sup>2</sup>=0.9698 to 0.9861). These compounds are responsible for obstruction of harmful radical associated biochemical reactions in biological systems. Pigmented metabolites also tested for attributive biological properties against pathogenic bacteria showed prominent inhibition towards Gram-positive organisms (31.25 to 62.5 mu g ml<sup>-1</sup>). From this study, it may be suggested that the marine bacterium PIGB 184 could be used as a potential bio-resource for antioxidants and needs to be worked out for mass production
dc.language.iso en
dc.publisher Springer
dc.relation.requires Appl_Biochem_Biotechnol_179_155.jpg
dc.rights An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2016] Springer
dc.subject MICROBIOLOGY::General
dc.subject MICROBIOLOGY::Physiology, biochemistry, biophysics
dc.subject AQUATIC ECOLOGY, PRODUCTIVITY::Environmental effects
dc.subject AQUATIC RESOURCES::Natural products
dc.title Antioxidative metabolites synthesized by marine pigmented vibrio sp. and its protection on oxidative deterioration of membrane lipids
dc.type Journal Article


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