Isolation and structure elucidation of halymeniaol, a new antimalarial sterol derivative from the red alga Halymenia floresii
Date
2018Author
Meesala, S.
Gurung, P.
Karmodiya, K.
Parameswaran, P.S.
Watve, M.G.
Metadata
Show full item recordAbstract
A new mono-hydroxy acetylated sterol derivative: 12?-hydroxy-3?, 15?, 16?-triacetoxy-cholest-5-en-7-one (halymeniaol) (1), and cholesterol (2) were isolated from the marine red alga Halymenia floresii. The structure of the compound 1 (halymeniaol) was established from its spectral data, derived from HRMS/MS and 2D NMR. Compound 1 exhibited growth inhibitory activity against chloroquine-resistant Plasmodium falciparum 3D7 strain with an IC50 of 3.0 ?M.
Collections
- Scholarly literature [8843]