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dc.contributor.authorAnas, A.
dc.contributor.authorSobhanan, J.
dc.contributor.authorSulfiya, K.M.
dc.contributor.authorJasmin, C.
dc.contributor.authorSreelakshmi, P.K.
dc.contributor.authorBiju, V.
dc.date.accessioned2021-09-30
dc.date.accessioned2021-10-01T07:25:53Z
dc.date.available2021-09-25
dc.date.available2021-10-01T07:25:53Z
dc.date.issued2021
dc.identifier.citationJournal of Photochemistry and Photobiology C: Photochemistry Reviews, vol.49; 2021; Article no: 100452
dc.identifier.issn1389-5567
dc.identifier.otherhttps://www.sciencedirect.com/science/article/abs/pii/S1389556721000514
dc.identifier.urihttps://doi.org/10.1016/J.JPHOTOCHEMREV.2021.100452
dc.identifier.urihttps://drs.nio.org/drs/handle/2264/8742
dc.descriptionIF2020 - 12.927
dc.description.abstractPhotodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) combine light and photosensitizers to treat cancers and microbial infections, respectively. In PACT, the excitation of a photosensitizer drug with appropriate light generates reactive oxygen species (ROS) that kill pathogens in the proximity of the drug. PACT has considerably advanced with new light sources, biocompatible photosensitizers, bioconjugate methods, and efficient ROS production. The PACT technology has evolved to compete with or replace antibiotics, reducing the burden of antibiotic resistance. This review updates recent advances in PACT, with special references to light sources, photosensitizers, and emerging applications to microbial infestations. We also discuss PACT applied to COVID-19 causing SARS-CoV-2 treatment and disinfecting food materials and water. Finally, we discuss the pathogen selectivity and efficiency of PACT.
dc.languageen
dc.publisherElsevier
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titleAdvances in photodynamic antimicrobial chemotherapy
dc.typeJournal Article
dc.affiliation.authorCSIR-National Institute of Oceanography, Kochi, Kerala, India


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